Preheat your oven to 350°F (175°C) and grease a loaf pan.

In a bowl, whisk together the flour, baking powder, baking soda, and salt.

In a separate large bowl, cream the softened butter and sugar until light and fluffy.

Add eggs one at a time, mixing well after each addition.

Stir in the vanilla extract and buttermilk until combined.

Gradually add the dry ingredients to the wet mixture, stirring until just combined.

Gently fold in the fresh blueberries, being careful not to crush them.

Pour the batter into the prepared loaf pan, smoothing the top.

Bake in the preheated oven for 50-60 minutes or until a toothpick comes out clean.

Allow to cool in the pan for 10 minutes before transferring to a wire rack to cool completely.