Preheat your oven to 375°F (190°C).
In a bowl, mix chipotle chili powder, garlic powder, onion powder, cumin, salt, and pepper.
Rub the spice mixture evenly over each chicken breast.
Heat olive oil in a large skillet over medium-high heat.
Add the chicken breasts to the skillet and sear for 3-4 minutes on each side until golden brown.
Transfer the chicken to a baking dish.
Bake in the preheated oven for 15-20 minutes until cooked through.
Use a meat thermometer to ensure the internal temperature reaches 165°F (75°C).
Remove from the oven and let it rest for 5 minutes.
Garnish with fresh cilantro and serve with lime wedges.