Gather all ingredients and equipment.
In a blender, combine mayonnaise, chipotle peppers, and adobo sauce.
Add lime juice, garlic powder, and onion powder.
Blend until smooth and well combined.
Taste and adjust seasoning with salt as needed.
If you prefer a thinner sauce, add a little water and blend again.
Transfer the sauce to a bowl or jar.
Cover and refrigerate for at least 30 minutes to let flavors meld.
Before serving, stir the sauce well.
Garnish with fresh cilantro if desired.